Article
In vitro expression of osteoblastic markers in cells isolated from normal fetal and postnatal human bone and from bone of patients with osteogenesis imperfecta.
Journal of cellular physiology - 1 Dec 1993
Mörike M, Schulz M, Brenner R E, Bushart G B, Teller W M, Vetter U
Abstract excerpt
We studied the expression of osteoblastic markers in cultured cells isolated from the bone of 15 patients with different clinical forms of osteogenesis imperfecta (OI) and of seven fetal and postnatal controls. Cultured bone cells of ten OI patients produced abnormal collagen type I. Similar to controls, OI bone cells produced predominantly collagen type I with traces of collagen types III and V. The 1,25(OH)2...
Topics
- Alkaline Phosphatase
- Biomarkers
- Bone and Bones
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Child
- Child, Preschool
- Collagen
- Electrophoresis, Polyacrylamide Gel