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Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome

4 May 2016

Abstract excerpt

BACKGROUND: Osteogenesis Imperfecta (OI) (OMIM %259450) is a heterogeneous group of inherited disorders characterized by increased bone fragility, with clinical severity ranging from mild to lethal. The majority of OI cases are caused by mutations in COL1A1 or COL1A2. Bruck Syndrome (BS) is a further recessively-inherited OI-like phenotype in which bone fragility is associated with the unusual finding of pterygia...

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PMID: 27146342
DOI: 10.1186/s12881-016-0301-7

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