Article
Functional assembly of fragments from bisected smooth muscle myosin light chain kinase.
The Journal of biological chemistry - 1 Sept 2000
Padre R C, Stull J T
Abstract excerpt
The C-terminal regulatory segment of smooth muscle myosin light chain kinase folds back on its catalytic core to inhibit kinase activity. This regulatory segment consists of autoinhibitory residues linking the catalytic core to the calmodulin-binding sequence and perhaps additional C-terminal residues including an immunoglobulin-like motif. However, mutational and biochemical analyses showed no specific...
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