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Article

The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins.

Genes & development - 15 Jun 1994

Lygerou Z, Mitchell P, Petfalski E, Séraphin B, Tollervey D

Abstract excerpt

Two forms of the yeast 5.8S rRNA are generated from a large precursor by distinct processing pathways. Cleavage at site A3 is required for synthesis of the major, short form, designated 5.8S(S), but not for synthesis of the long form, 5.8S(L). To identify components required for A3 cleavage, a bank of temperature-sensitive lethal mutants was screened for those with a reduced ratio of 5.8S(S):5.8S(L). The pop1-1...

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Source

Identifiers

PMID: 7926742
DOI: 10.1101/gad.8.12.1423

Genes

POP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins.PMID 7926742Read ↗

Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo.Semantic proximity Read ↗

Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.Semantic proximity Read ↗

An essential protein-binding domain of nuclear RNase P RNA.Semantic proximity Read ↗

RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.Semantic proximity Read ↗

The novel R211Q POP1 homozygous mutation causes different pathogenesis and skeletal changes from those of previously reported POP1-associated anauxetic dysplasia.Semantic proximity Read ↗

Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs.Semantic proximity Read ↗

Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes.Semantic proximity Read ↗

The RNA of RNase MRP is required for normal processing of ribosomal RNA.Semantic proximity Read ↗

Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.Semantic proximity Read ↗

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