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Article

Identification of a functional core in the RNA component of RNase MRP of budding yeasts.

Nucleic acids research - 1 Jan 2004

Li Xing, Zaman Sephorah, Langdon Yvette, Zengel Janice M, Lindahl Lasse

Abstract excerpt

RNase MRP is an endonuclease participating in ribosomal RNA processing. It consists of one RNA and at least nine protein subunits. Using oligonucleotide-directed mutagenesis, we analyzed the functional role of five of the hairpins in the secondary structure of the RNA subunit of Saccharomyces cerevisiae RNase MRP. Deletion of an entire hairpin was either lethal or resulted in very poor growth. However, peripheral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15254272
DOI: 10.1093/nar/gkh689
PMCID: PMC484176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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