Article
Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages.
Genes & development - 1 Jul 1991
Karwan R, Bennett J L, Clayton D A
Abstract excerpt
RNase MRP is a site-specific endoribonuclease that processes primer RNA from the leading-strand origin of mammalian mitochondrial DNA replication. It is present in active form as isolated from the nucleus, suggesting a bipartite cellular location and function. The relatively high abundance of nuc...
Topics
- Animals
- Base Composition
- Base Sequence
- Cell Nucleus
- Endoribonucleases
- HeLa Cells
- Humans
- Hydrolysis
- Mice
- Molecular Sequence Data
- Molecular Weight
- Mutation
- RNA Processing, Post-Transcriptional
- RNA, Catalytic
- RNA, Ribosomal
- Ribonuclease P
- Ribonucleoproteins