Chloroquine resistance in Plasmodium falciparum is not reversed by BIBW-22, a compound reversing the multidrug resistance phenotype in mammalian cancer cells.

doi:10.1016/0006-2952(93)90107-8

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Article

Chloroquine resistance in Plasmodium falciparum is not reversed by BIBW-22, a compound reversing the multidrug resistance phenotype in mammalian cancer cells.

Biochemical pharmacology - 19 Oct 1993

Dieckmann-Schuppert A, Bamberger U, Schwarz R T

Abstract excerpt

The pteridine derivative BIBW-22 (4-[N-(2-hydroxy-2-methyl-propyl)-ethanolamino]-2,7-bis(cis-2,6-di methyl-morpholino)-6-phenylpteridine), which had been developed for the treatment of multidrug-resistant cancer and binds to P-glycoprotein, was tested against chloroquine resistant Plasmodium falc...

Topics

Animals
Cell Survival
Chloroquine
Drug Resistance
Microbial Sensitivity Tests
Morpholines
Phenotype
Plasmodium falciparum
Triamterene
Tumor Cells, Cultured

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