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Article

Herpes simplex virus latency-associated transcript is a stable intron.

1 Feb 1991

Abstract excerpt

The latency-associated transcript (LAT) is the major viral transcript detected by in situ hybridization of mouse and human sensory ganglia latently infected with herpes simplex virus type 1. The last 750 bases of LAT are complementary to infected-cell polypeptide 0, a herpes simplex virus type 1 immediate-early gene that encodes a transactivating protein that may facilitate re-activation of the virus from the...

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PMID: 1846963
DOI: 10.1073/pnas.88.3.790

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Related research

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Research trail→

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Herpes simplex virus latency-associated transcript is a stable intron.PMID 1846963Read ↗

The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosineSemantic proximity Read ↗

Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.Semantic proximity Read ↗

Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit ApoptosisSemantic proximity Read ↗

Experimental investigation of herpes simplex virus latencySemantic proximity Read ↗

Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection.Semantic proximity Read ↗

HSV LAT and neuronal survival.Semantic proximity Read ↗

Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell LineSemantic proximity Read ↗

The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells.Semantic proximity Read ↗

Herpes Simplex Virus 1 Small Noncoding RNAs 1 and 2 Activate the Herpesvirus Entry Mediator Promoter.Semantic proximity Read ↗

The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal gangliaSemantic proximity Read ↗

Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.Semantic proximity Read ↗

A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics.Semantic proximity Read ↗

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