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Article

Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.

Journal of cell science - 1 Aug 1993

Byrne S M, Hoffman C S

Abstract excerpt

An important eukaryotic signal transduction pathway involves the regulation of the effector enzyme adenylate cyclase, which produces the second messenger, cAMP. Previous genetic analyses demonstrated that glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene requires the function of adenylate cyclase, encoded by the git2 gene. As mutations in git2 and in six additional git genes are...

Topics

3',5'-Cyclic-AMP Phosphodiesterases
Adenylyl Cyclases
Cyclic AMP
Enzyme Activation
Genes, Fungal
Genetic Complementation Test
Glucose
Mutation
Schizosaccharomyces
Signal Transduction

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Identifiers

PMID: 8227198
DOI: 10.1242/jcs.105.4.1095
PMCID: PMC4422216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8227198-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.PMID 8227198Read ↗

Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.Semantic proximity Read ↗

Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).Semantic proximity Read ↗

Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.Semantic proximity Read ↗

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.Semantic proximity Read ↗

Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation.Semantic proximity Read ↗

Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.Semantic proximity Read ↗

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.Semantic proximity Read ↗

Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.Semantic proximity Read ↗

The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway.Semantic proximity Read ↗

Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.Semantic proximity Read ↗

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.Semantic proximity Read ↗

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