Article
Immunohistochemical detection of mutant P53 protein and human papillomavirus-related E6 protein in anal cancers.
Diseases of the colon and rectum - 1 Nov 1993
Jakate S M, Saclarides T J
Abstract excerpt
PURPOSE: The wild-type P53 protein, a product of the P53 gene, is a normal growth controlling protein. Mutation of the P53 gene generates a mutant P53 protein which promotes tumor formation through loss of growth suppression. Some of the agents responsible for P53 gene mutation are known, one of which may be tumorigenic human papillomavirus (HPV) infection. Anal cancers are demonstrating a changing trend in the...
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