Article
Immunohistochemical detection of mutant P53 protein and human papillomavirus-related E6 protein in anal cancers.
Diseases of the colon and rectum - 1 Nov 1993
Jakate S M, Saclarides T J
Abstract excerpt
PURPOSE: The wild-type P53 protein, a product of the P53 gene, is a normal growth controlling protein. Mutation of the P53 gene generates a mutant P53 protein which promotes tumor formation through loss of growth suppression. Some of the agents responsible for P53 gene mutation are known, one of...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Anus Neoplasms
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Markers
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae