An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene.

doi:10.1378/chest.104.5.1606

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Article

An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene.

Chest - 1 Nov 1993

Hiyama K, Hasegawa K, Ishioka S, Takahashi N, Yamakido M

Abstract excerpt

Molecular analysis of a metastatic lesion of an atypical carcinoid tumor of the lung obtained from a 77-year-old man at autopsy revealed a point mutation in the p53 gene and a deletion in the retinoblastoma (Rb) mRNA. This case suggests that both these antioncogenes may be involved in the progres...

Topics

Aged
Base Sequence
Carcinoid Tumor
Genes, Retinoblastoma
Genes, p53
Humans
Lung Neoplasms
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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