Article
The multifactorial nature of MHC-linked susceptibility to insulin-dependent diabetes.
Autoimmunity - 1 Jan 1993
Segurado O G, Arnaiz-Villena A, Wank R, Schendel D J
Abstract excerpt
Several lines of evidence suggest that major histocompatibility complex (MHC)-linked susceptibility to insulin-dependent diabetes mellitus (IDDM) is not restricted to the presence or absence of any single gene product. The existence of population-specific haplotypes associated with IDDM supports...
Topics
- Animals
- Autoimmune Diseases
- Diabetes Mellitus, Type 1
- Disease Models, Animal
- Disease Susceptibility
- Genetic Markers
- Genetic Predisposition to Disease
- HLA-D Antigens
- Humans
- Linkage Disequilibrium
- Major Histocompatibility Complex
- Mice
- Models, Biological
- Rats
- Self Tolerance
- T-Lymphocyte Subsets
- Virus Diseases