Article
BQ-123 identifies heterogeneity and allosteric interactions at the rat heart endothelin receptor.
Biochemical and biophysical research communications - 15 Oct 1993
Sokolovsky M
Abstract excerpt
Studies of the binding of endothelin-1 (ET-1) to its receptors in the rat heart, as well as kinetic measurements in the presence and absence of the specific antagonist BQ-123, appear to exclude a scheme of simple competitive inhibition and an interaction of ET-1 with a homogeneous population of r...
Topics
- Allosteric Regulation
- Animals
- Cells, Cultured
- Endothelin Receptor Antagonists
- Endothelins
- Genetic Variation
- In Vitro Techniques
- Kinetics
- Male
- Myocardium
- Peptides, Cyclic
- Phosphatidylinositols