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Article

Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms.

Pharmacogenetics - 1 Jun 2004

Sandilands Alastair, Yeo Giles, Brown Morris J, O'Shaughnessy Kevin M

Abstract excerpt

OBJECTIVES: The human beta1-adrenoceptor (beta1-AR) is an important therapeutic target for cardiovascular diseases and has two common functional polymorphisms (49S>G and 389R>G). These polymorphisms have only been studied in isolation, however, and not in the context of the four haplotypes (SR, SG, GR and GG) that exist in native beta1-ARs. METHODS: To address this, the function of each of the receptor haplotypes...

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PMID: 15247626
DOI: 10.1097/00008571-200406000-00003

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