The relative efficiency of the Hardy-Weinberg equilibrium-likelihood and the conditional on parental genotype-likelihood methods for candidate-gene association studies.

Article

The relative efficiency of the Hardy-Weinberg equilibrium-likelihood and the conditional on parental genotype-likelihood methods for candidate-gene association studies.

American journal of human genetics - 1 Dec 1995

Knapp M, Wassmer G, Baur M P

Abstract excerpt

Selecting a control group that is perfectly matched for ethnic ancestry with a group of affected individuals is a major problem in studying the association of a candidate gene with a disease. This problem can be avoided by a design that uses parental data in place of nonrelated controls. Schaid a...

Topics

Genetic Diseases, Inborn
Genotype
Humans
Likelihood Functions
Models, Genetic

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