Article
Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat.
Clinical & experimental metastasis - 1 Feb 1998
Himelstein B P, Lee E J, Sato H, Seiki M, Muschel R J
Abstract excerpt
The 92-kDa type IV collagenase (MMP-9) is a metalloproteinase frequently localized in both tumor stroma and in tumor cells, particularly at the tumor invasion front. To explore the factors regulating transcriptional activation of MMP-9 in stromal cells, we used a model system in which fibroblast...
Topics
- Animals
- Cell Communication
- Cell Line, Transformed
- Collagenases
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Matrix Metalloproteinase 9
- Mutation
- Nucleic Acid Conformation
- Promoter Regions, Genetic
- Rats
- Transcription Factors