Article
The cobT gene of Salmonella typhimurium encodes the NaMN: 5,6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, an intermediate in the synthesis of the nucleotide loop of cobalamin.
Journal of bacteriology - 1 Jun 1994
Trzebiatowski J R, O'Toole G A, Escalante-Semerena J C
Abstract excerpt
We present in vitro evidence which demonstrates that CobT is the nicotinate nucleotide:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (EC 2.4.2.21) that catalyzes the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, a biosynthetic intermediate of the pathway that...
Topics
- Amino Acid Sequence
- Benzimidazoles
- Chromosome Mapping
- Genes, Bacterial
- Molecular Sequence Data
- Multienzyme Complexes
- Mutation
- Nucleotidyltransferases
- Pentosyltransferases
- Ribonucleotides
- Salmonella typhimurium
- Sequence Homology, Amino Acid
- Vitamin B 12