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Article

A Salmonella typhimurium cobalamin-deficient mutant blocked in 1-amino-2-propanol synthesis.

Journal of bacteriology - 1 Apr 1992

Grabau C, Roth J R

Abstract excerpt

Salmonella typhimurium synthesizes cobalamin (vitamin B12) when grown under anaerobic conditions. All but one of the biosynthetic genes (cob) are located in a single operon which includes genes required for the production of cobinamide and dimethylbenzimidazole, as well as the genes needed to form cobalamin from these precursors. We isolated strains carrying mutations (cobD) which are unlinked to any of the...

Topics

Alcohol Oxidoreductases
Chromosome Mapping
Cobalt
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genes, Dominant
Mutation
Operon
Phenotype
Propanolamines
RNA, Messenger
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Vitamin B 12

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Identifiers

PMID: 1551838
DOI: 10.1128/jb.174.7.2138-2144.1992
PMCID: PMC205831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1551838-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A Salmonella typhimurium cobalamin-deficient mutant blocked in 1-amino-2-propanol synthesis.PMID 1551838Read ↗

cobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium.Semantic proximity Read ↗

The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.Semantic proximity Read ↗

Cobalamin-dependent 1,2-propanediol utilization by Salmonella typhimurium.Semantic proximity Read ↗

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2.Semantic proximity Read ↗

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Repression of the cob operon of Salmonella typhimurium by adenosylcobalamin is influenced by mutations in the pdu operon.Semantic proximity Read ↗

The cobT gene of Salmonella typhimurium encodes the NaMN: 5,6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, an intermediate in the synthesis of the nucleotide loop of cobalamin.Semantic proximity Read ↗

The end of the cob operon: evidence that the last gene (cobT) catalyzes synthesis of the lower ligand of vitamin B12, dimethylbenzimidazole.Semantic proximity Read ↗

Identification of 5,6-dimethylbenzimidazole as the Co alpha ligand of the cobamide synthesized by Salmonella typhimurium. Nutritional characterization of mutants defective in biosynthesis of the imidazole ring.Semantic proximity Read ↗

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One pathway can incorporate either adenine or dimethylbenzimidazole as an alpha-axial ligand of B12 cofactors in Salmonella enterica.Semantic proximity Read ↗

Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli.Semantic proximity Read ↗

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