Article
Identification of 5,6-dimethylbenzimidazole as the Co alpha ligand of the cobamide synthesized by Salmonella typhimurium. Nutritional characterization of mutants defective in biosynthesis of the imidazole ring.
The Journal of biological chemistry - 5 Jul 1992
Johnson M G, Escalante-Semerena J C
Abstract excerpt
The Co beta-cyano derivative of the cobamide isolated from Salmonella typhimurium was identified as Co alpha-(alpha-5,6-dimethylbenzimidazolyl)-Co beta-cyanocobamide, indicating that this bacterium synthesizes 5,6-dimethylbenzimidazole (DMB) de novo. We found that mutants deficient in the synthes...
Topics
- Benzimidazoles
- Chromatography, High Pressure Liquid
- Cobamides
- Imidazoles
- Magnetic Resonance Spectroscopy
- Mutation
- Salmonella typhimurium
- Spectrometry, Mass, Fast Atom Bombardment
- Spectrophotometry, Ultraviolet
- Vitamin B 12