Article
CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2.
The Journal of biological chemistry - 27 Nov 1998
Tsang A W, Escalante-Semerena J C
Abstract excerpt
The cobB gene of Salmonella typhimurium LT2 has been isolated and genetically and biochemically characterized. cobB was located by genetic means to the 27-centisome region of the chromosome. Genetic crosses established the gene order to be cobB pepT phoQ, and the direction of cobB transcription w...
Topics
- Amino Acid Sequence
- Base Pairing
- Base Sequence
- Crosses, Genetic
- Genotype
- Kinetics
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis, Site-Directed
- Nucleotidyltransferases
- Pentosyltransferases
- Point Mutation
- Recombinant Proteins