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Article

Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.

Biochimica et biophysica acta - 1 Jan 2014

Chan Chi Ho, Newmister Sean A, Talyor Keenan, Claas Kathy R, Rayment Ivan, Escalante-Semerena Jorge C

Abstract excerpt

BACKGROUND: Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucleotide base substrates (e.g., benzimidazoles, purines, phenolics) that are incorporated into cobamides. METHODS: Structural investigations of two members of the CobT family of enzymes in complex with...

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Identifiers

PMID: 24121107
DOI: 10.1016/j.bbagen.2013.09.038
PMCID: PMC3900240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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