Antithrombin and its inherited deficiencies.

Abstract excerpt

Human antithrombin is the major inhibitor of the coagulation serine proteases accounting for approximately 80% of the thrombin inhibitory activity of plasma. It is a member of the serpin family of serine protease inhibitors and in common with some other members of this family it undergoes a dramatic increase in its inhibitory activity in the presence of heparin and other sulphated glycosaminoglycans. Two...

Topics

• Amino Acid Sequence
• Antithrombins
• Base Sequence
• Binding Sites
• Disease Susceptibility
• Female
• Humans
• Male
• Models, Molecular
• Molecular Sequence Data
• Multigene Family
• Mutation