Article
An overview of the mechanism of action of antithrombin and its inherited deficiency states.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 1994
Blajchman M A
Abstract excerpt
Antithrombin is the most important physiological inhibitor of the various activated serine protease clotting factors, particularly thrombin. In vitro, the inhibition of thrombin by antithrombin is very slow; but greatly enhanced by heparin and related glycosaminoglycans. When a serine protease in...
Topics
- Amino Acid Sequence
- Antithrombin III
- Antithrombin III Deficiency
- Enzyme Activation
- Factor Xa
- Female
- Humans
- Incidence
- Molecular Sequence Data
- Mutation
- Pregnancy
- Pregnancy Complications, Hematologic