Molecular genetics of antithrombin deficiency.

doi:10.1016/s0268-960x(96)90034-x

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Article

Molecular genetics of antithrombin deficiency.

Blood reviews - 1 Jun 1996

Lane D A, Kunz G, Olds R J, Thein S L

Abstract excerpt

Antithrombin is the major proteinase inhibitor of thrombin and other blood coagulation proteinases. Antithrombin has two functional domains, a heparin binding site and a reactive centre (that complexes and inactivates the proteinase). Its deficiency results in an increased risk of venous thromboe...

Topics

Antithrombin III
Antithrombin III Deficiency
Crystallography, X-Ray
Humans
Mutation
Polymorphism, Genetic

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