Article
Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 1994
Chen W H, Morriss-Kay G M, Copp A J
Abstract excerpt
Curly tail mouse mutant embryos (ct/ct) develop spinal neural tube defects (NTD) in 54% of cases, comprising isolated tail flexion defects and spinal bifida with tail flexion defects. Both types of spinal NTD result from delayed closure of the posterior neuropore (PNP). Previous studies (Seller e...
Topics
- Animals
- Dose-Response Relationship, Drug
- Embryo, Mammalian
- Embryonic and Fetal Development
- Female
- Incidence
- Male
- Mice
- Mice, Mutant Strains
- Neural Tube Defects
- Phenotype
- Spinal Dysraphism
- Tail
- Time Factors
- Tretinoin