Article
Expression of the Axd (axial defects) mutation in the mouse is insensitive to retinoic acid at low dose.
The Journal of experimental zoology - 1 Dec 1990
Haviland M B, Essien F B
Abstract excerpt
The Axd mutation in the mouse acts by an unknown mechanism to cause lumbosacral open neural tube defects and a variety of tail anomalies. Retinoic acid (RA) plays a number of different physiological and developmental roles and has been shown to affect neurulation in mice and other species. Indeed...
Topics
- Animals
- Crosses, Genetic
- Female
- Gene Expression
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Neural Tube Defects
- Survival Rate
- Tail
- Tretinoin