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Article

Active Efflux System for Cisplatin in Cisplatin‐resistant Human KB Cells

1 Apr 1994

Abstract excerpt

Mutants, KCP-4 and PC-5, resistant to an anticancer agent, cisplatin, were selected in multiple steps from human epidermoid KB carcinoma cells and human prostate PC-3 carcinoma cells, respectively. KCP-4 and PC-5 were 63 and 10 fold more resistant to cisplatin than the parental cells, respectively. KCP-4 cells exhibited increased resistance to cisplatin analogues and were also slightly cross-resistant to...

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PMID: 8200854
DOI: 10.1111/j.1349-7006.1994.tb02376.x

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