Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis.

Biochimica et biophysica acta - 15 Apr 2005

Esapa Christopher, Moffitt Jennifer H, Novials Anna, McNamara Catherine M, Levy Jonathan C, Laakso Marku, Gomis Ramon, Clark Anne

Abstract excerpt

The over-expression of the islet amyloid polypeptide (IAPP) gene could be a causal factor for islet amyloidosis and beta-cell destruction in Type 2 diabetes (T2DM). An IAPP gene promoter polymorphism, IAPP-132G to A, has been associated with T2DM in Spain. To investigate this polymorphism in other cohorts and in relation to therapy, DNA from 425 T2DM and 279 unrelated, non-diabetic UK subjects (ND) and 102 T2DM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Amyloidosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to England

Share to Finland

Share to Islet Amyloid Polypeptide

Share to Islets of Langerhans

Share to Pancreatic Diseases

Source

Identifiers

PMID: 15878744
DOI: 10.1016/j.bbadis.2005.02.001

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis.PMID 15878744Read ↗

Studies of variability in the islet amyloid polypeptide gene in relation to Type 2 diabetes.Semantic proximity Read ↗

Apolipoprotein E genotype, islet amyloid deposition and severity of Type 2 diabetes.Semantic proximity Read ↗

Islet amyloid polypeptide gene: no evidence of abnormal promoter region in thirty-five type 2 diabetic patients.Semantic proximity Read ↗

Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study.Semantic proximity Read ↗

The islet amyloid polypeptide gene and non-insulin-dependent diabetes mellitus in south Indians.Semantic proximity Read ↗

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.Semantic proximity Read ↗

Islet amyloid polypeptide (IAPP) gene analysis in a Japanese diabetic with marked islet amyloid deposition.Semantic proximity Read ↗

NFkappaB1 gene does not affect type 1 diabetes predisposition in a Spanish population.Semantic proximity Read ↗

Restriction fragment length polymorphisms near the islet amyloid polypeptide gene in Japanese subjects.Semantic proximity Read ↗

Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.