Article
Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells.
Hearing research - 1 Mar 1998
Iwai H, Tomoda K, Hosaka N, Miyashima S, Suzuka Y, Ikeda H, Lee S, Inaba M, Ikehara S, Yamashita T
Abstract excerpt
Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells The MRL/lpr mouse, which has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, shows an accumulation of abnormal immunocompetent cells and SLE-like disease. It has recently b...
Topics
- Animals
- Autoimmune Diseases
- Cell Transplantation
- Chimera
- Cochlea
- Disease Models, Animal
- Endothelium, Vascular
- Evoked Potentials, Auditory, Brain Stem
- Flow Cytometry
- Hearing Loss, Sensorineural
- Immunity, Cellular
- Immunoglobulin G
- Immunohistochemistry
- Mice
- Mice, Inbred C57BL