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Article

Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells.

Hearing research - 1 Mar 1998

Iwai H, Tomoda K, Hosaka N, Miyashima S, Suzuka Y, Ikeda H, Lee S, Inaba M, Ikehara S, Yamashita T

Abstract excerpt

Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells The MRL/lpr mouse, which has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, shows an accumulation of abnormal immunocompetent cells and SLE-like disease. It has recently been reported that this mouse also manifests sensorineural hearing loss (SHL) with cochlear pathology at 20 weeks of...

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Identifiers

PMID: 9557987
DOI: 10.1016/s0378-5955(98)00015-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells.PMID 9557987Read ↗

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Significant role for Fas in the pathogenesis of autoimmune diabetes.Semantic proximity Read ↗

Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.Semantic proximity Read ↗

A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice.Semantic proximity Read ↗

Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.Semantic proximity Read ↗

Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Semantic proximity Read ↗

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