Article
DNA contents and chromosomes of clonal lines of transformed rat liver epithelial cells and of cells from their derived tumors.
Carcinogenesis - 1 May 1994
Steadman J S, Lee L W, Smith G J, Grisham J W
Abstract excerpt
Clonal lines of transformed rat liver epithelial cells, derived from a single population of cloned diploid rat liver epithelial (stem-like) cell line (WB-F344) by exposure in vitro to N-methyl-N'-nitro-N- nitrosoguanidine (MNNG), produce hepatocellular carcinomas, hepatoblastomas and adenocarcino...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosome Deletion
- DNA
- DNA, Neoplasm
- Epithelium
- Genetic Markers
- Karyotyping
- Liver
- Liver Neoplasms, Experimental
- Male
- Methylnitronitrosoguanidine
- Phenotype
- Ploidies
- Rats
- Rats, Inbred F344