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DNA contents and chromosomes of clonal lines of transformed rat liver epithelial cells and of cells from their derived tumors.

Carcinogenesis - 1 May 1994

Steadman J S, Lee L W, Smith G J, Grisham J W

Abstract excerpt

Clonal lines of transformed rat liver epithelial cells, derived from a single population of cloned diploid rat liver epithelial (stem-like) cell line (WB-F344) by exposure in vitro to N-methyl-N'-nitro-N- nitrosoguanidine (MNNG), produce hepatocellular carcinomas, hepatoblastomas and adenocarcinomas in syngeneic rats (Tsao and Grisham, Am. J. Pathol., 127, 168-181, 1987). In this study we show that these clonal...

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PMID: 8200102
DOI: 10.1093/carcin/15.5.963

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