Article
Translational regulation of the Escherichia coli threonyl-tRNA synthetase gene: structural and functional importance of the thrS operator domains.
Biochimie - 1 Jan 1993
Brunel C, Romby P, Moine H, Caillet J, Grunberg-Manago M, Springer M, Ehresmann B, Ehresmann C
Abstract excerpt
Previous work showed that E coli threonyl-tRNA synthetase (ThrRS) binds to the leader region of its own mRNA and represses its translation by blocking ribosome binding. The operator consists of four distinct domains, one of them (domain 2) sharing structural analogies with the anticodon arm of th...
Topics
- Base Sequence
- Escherichia coli
- Gene Deletion
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Operator Regions, Genetic
- Point Mutation
- Protein Biosynthesis
- Protein Structure, Secondary