Article
The modular structure of Escherichia coli threonyl-tRNA synthetase as both an enzyme and a regulator of gene expression.
Molecular microbiology - 1 Feb 2003
Caillet Joël, Nogueira Teresa, Masquida Benoît, Winter Flore, Graffe Monique, Dock-Brégeon Anne-Catherine, Torres-Larios Alfredo, Sankaranarayanan Rajan, Westhof Eric, Ehresmann Bernard, Ehresmann Chantal, Romby Pascale, Springer Mathias
Abstract excerpt
In addition to its role in tRNA aminoacylation, Escherichia coli threonyl-tRNA synthetase is a regulatory protein which binds a site, called the operator, located in the leader of its own mRNA and inhibits translational initiation by competing with ribosome binding. This work shows that the two essential steps of regulation, operator recognition and inhibition of ribosome binding, are performed by different...
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