Article
Molecular mimicry in translational control of E. coli threonyl-tRNA synthetase gene. Competitive inhibition in tRNA aminoacylation and operator-repressor recognition switch using tRNA identity rules.
Nucleic acids research - 11 Nov 1992
Romby P, Brunel C, Caillet J, Springer M, Grunberg-Manago M, Westhof E, Ehresmann C, Ehresmann B
Abstract excerpt
We previously showed that: (i) E.coli threonyl-tRNA synthetase (ThrRS) binds to the leader of its mRNA and represses translation by preventing ribosome binding to its loading site; (ii) the translational operator shares sequence and structure similarities with tRNA(Thr); (iii) it is possible to s...
Topics
- Acylation
- Anticodon
- Base Sequence
- Binding, Competitive
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Methionine-tRNA Ligase
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Operator Regions, Genetic
- Protein Biosynthesis
- RNA, Bacterial