Article
The Escherichia coli threonyl-tRNA synthetase gene contains a split ribosomal binding site interrupted by a hairpin structure that is essential for autoregulation.
Molecular microbiology - 1 Aug 1998
Sacerdot C, Caillet J, Graffe M, Eyermann F, Ehresmann B, Ehresmann C, Springer M, Romby P
Abstract excerpt
The expression of the gene encoding Escherichia coli threonyl-tRNA synthetase (ThrRS) is negatively autoregulated at the translational level. ThrRS binds to its own mRNA leader, which consists of four structural and functional domains: the Shine-Dalgarno (SD) sequence and the initiation codon reg...
Topics
- Base Sequence
- Binding Sites
- DNA Primers
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Biosynthesis
- RNA, Bacterial