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The Escherichia coli threonyl-tRNA synthetase gene contains a split ribosomal binding site interrupted by a hairpin structure that is essential for autoregulation.

Molecular microbiology - 1 Aug 1998

Sacerdot C, Caillet J, Graffe M, Eyermann F, Ehresmann B, Ehresmann C, Springer M, Romby P

Abstract excerpt

The expression of the gene encoding Escherichia coli threonyl-tRNA synthetase (ThrRS) is negatively autoregulated at the translational level. ThrRS binds to its own mRNA leader, which consists of four structural and functional domains: the Shine-Dalgarno (SD) sequence and the initiation codon region (domain 1); two upstream hairpins (domains 2 and 4) connected by a single-stranded region (domain 3). Using a...

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Identifiers

PMID: 9767575
DOI: 10.1046/j.1365-2958.1998.00995.x

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