Article
The translational regulation of threonyl-tRNA synthetase. Functional relationship between the enzyme, the cognate tRNA and the ribosome.
Biochimica et biophysica acta - 27 Aug 1990
Moine H, Ehresmann B, Romby P, Ebel J P, Grunberg-Manago M, Springer M, Ehresmann C
Abstract excerpt
The E. coli threonyl-tRNA synthetase gene is negatively autoregulated at the translational level by a direct binding of the enzyme to the leader region of the thrS mRNA. This region folds in four well-defined domains. The enzyme binds to the leader at two major sites: the first is a stem-loop structure located in domain II upstream of the translational initiation site (domain I) which shares structural analogies...
Topics
- Anticodon
- Base Sequence
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Genes, Bacterial
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation