Co-ordinate expression of the two threonyl-tRNA synthetase genes in Bacillus subtilis: control by transcriptional antitermination involving a conserved regulatory sequence.

Abstract excerpt

In Bacillus subtilis, two genes, thrS and thrZ, encode distinct threonyl-tRNA synthetase enzymes. Normally, only the thrS gene is expressed. Here we show that either gene, thrS or thrZ, is sufficient for normal cell growth and sporulation. Reducing the intracellular ThrS protein concentration induces thrZ expression in a dose-compensatory manner. Starvation for threonine simultaneously induces thrZ and stimulates...

Topics

• Bacillus subtilis
• Base Sequence
• Chromosomes, Bacterial
• DNA, Bacterial
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Enzymologic
• Genes, Bacterial
• Genes, Lethal
• Genes, Regulator
• Genotype