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Article

Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling

16 Nov 2013

Abstract excerpt

Increasing evidence supports the importance of cell extrinsic regulation in stem cell fate control. Hematopoietic stem cells (HSC) are responsive to local signals from their niche and to systemic feedback from progenitors and mature cells. The Notch ligand Delta-1 (DL1), a key component of the stem cell niche, regulates human hematopoietic lineage development in a dose-dependent manner and has been used...

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PMID: 24243972
DOI: 10.1182/blood-2013-08-520445

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