Article
Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Bicknell D C, Rowan A, Bodmer W F
Abstract excerpt
The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. Exon 1 (including the leader peptide sequence) and exon 2 were scr...
Topics
- Amino Acid Sequence
- Base Sequence
- Colorectal Neoplasms
- DNA, Neoplasm
- Exons
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Tumor Cells, Cultured
- beta 2-Microglobulin