Article
Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Bicknell D C, Rowan A, Bodmer W F
Abstract excerpt
The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. Exon 1 (including the leader peptide sequence) and exon 2 were screened separately. Six of 37 colorectal cell lines and 1 of 22 fresh tumors were shown to contain mutations, whereas no...
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