Article
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.
Antimicrobial agents and chemotherapy - 1 Feb 1996
Versalovic J, Shortridge D, Kibler K, Griffy M V, Beyer J, Flamm R K, Tanaka S K, Graham D Y, Go M F
Abstract excerpt
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA position...
Topics
- Anti-Bacterial Agents
- Base Sequence
- Clarithromycin
- Drug Resistance, Microbial
- Electrophoresis, Agar Gel
- Helicobacter pylori
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Protein Synthesis Inhibitors
- RNA, Ribosomal, 23S
- Sequence Homology, Nucleic Acid