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Article

Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines.

PloS one - 5 Aug 2010

Kalapala Sarath K, Hobbie Sven N, Böttger Erik C, Shcherbakov Dmitry

Abstract excerpt

Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of...

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Identifiers

PMID: 20700526
DOI: 10.1371/journal.pone.0011960
PMCID: PMC2916820

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Source receipt: pubmed, retrieved 7 Sept 2026.

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