Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus.

1 May 1994

Abstract excerpt

Merosin is the predominant laminin isoform in the basal lamina of striated muscle and peripheral nerve, and consists of M, B1 or S, and B2 chains. Here we have demonstrated that merosin is a native ligand for alpha-dystroglycan, an extracellular component of the dystrophin-glycoprotein complex. We have also mapped the mouse M chain gene, Lamm, to the same region of mouse chromosome 10 to which the dystrophia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Muscle metabolism and nutrition
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8188645
DOI: 10.1016/s0021-9258(17)36704-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus.PMID 8188645Read ↗

Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse.Semantic proximity Read ↗

Merosin and congenital muscular dystrophy.Semantic proximity Read ↗

Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models.Semantic proximity Read ↗

A Family of Laminin α2 Chain-Deficient Mouse Mutants: Advancing the Research on LAMA2-CMDSemantic proximity Read ↗

Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice.Semantic proximity Read ↗

Nerve pathology is prevented by linker proteins in mouse models for LAMA2 -related muscular dystrophySemantic proximity Read ↗

A single point mutation in the LN domain of LAMA2 causes muscular dystrophy and peripheral amyelination.Semantic proximity Read ↗

Laminin-111 Protein Therapy Reduces Muscle Pathology and Improves Viability of a Mouse Model of Merosin-Deficient Congenital Muscular DystrophySemantic proximity Read ↗

Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy.Semantic proximity Read ↗

Laminin-α2 is required for the maintenance of the myotendinous junction in vivo.Semantic proximity Read ↗

Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses.Semantic proximity Read ↗

Severe muscular dystrophy in mice that lack dystrophin and α7 integrinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.