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Article

Laminin-α2 is required for the maintenance of the myotendinous junction in vivo.

Matrix biology : journal of the International Society for Matrix Biology - 1 May 2026

Schedel Julia, Lin Shuo, Bock Thomas, Burri Dominik, Rüegg Markus A

Abstract excerpt

The myotendinous junction (MTJ) is a critical interface between muscle fibers and tendons, essential for force transmission between muscle and bone. Laminin-α2, a key extracellular matrix (ECM) component, is strongly enriched at this interface. Mutations in the LAMA2 gene cause LAMA2-related muscular dystrophy (LAMA2 MD), an early-onset severe congenital muscular dystrophy. Here, we examined the MTJ in dyW/dyW...

Topics

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Collagen
Disease Models, Animal
Extracellular Matrix
Laminin
Muscle Fibers, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Skeletal

Muscular Dystrophies

Source

Identifiers

PMID: 41856211
DOI: 10.1016/j.matbio.2026.03.003

Genes

LAMA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Laminin-α2 is required for the maintenance of the myotendinous junction in vivo.PMID 41856211Read ↗

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