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Nerve pathology is prevented by linker proteins in mouse models for LAMA2 -related muscular dystrophy

15 Mar 2023

Abstract excerpt

Abstract LAMA2-related muscular dystrophy (LAMA2 MD or MDC1A) is a devastating congenital muscular dystrophy that is caused by mutations in the LAMA2 gene encoding laminin-α2, the long chain of several heterotrimeric laminins. Laminins are essential components of the extracellular matrix that interface with underlying cells. The pathology of LAMA2 MD patients is dominated by an early-onset, severe muscular...

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PMID: 37038437
DOI: 10.1093/pnasnexus/pgad083

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