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Article

Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models.

15 Aug 1998

Abstract excerpt

Humans and mice with deficiency of the alpha2 subunit of the basement membrane protein laminin-2/merosin suffer from merosin-deficient congenital muscular dystrophy (MCMD). We have expressed a human laminin alpha2 chain transgene under the regulation of a muscle-specific creatine kinase promoter in mice with complete or partial deficiency of merosin. The transgene restores the synthesis and localization of...

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PMID: 9710454
DOI: 10.1172/jci3705

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Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models.PMID 9710454Read ↗

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