Article
Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice.
Neuromuscular disorders : NMD - 1 Mar 2003
Guo L T, Zhang X U, Kuang W, Xu H, Liu L A, Vilquin J-T, Miyagoe-Suzuki Y, Takeda S, Ruegg M A, Wewer U M, Engvall E
Abstract excerpt
Deficiency of laminin alpha2 is the cause of one of the most severe muscular dystrophies in humans and other species. It is not yet clear how particular mutations in the laminin alpha2 chain gene affect protein expression, and how abnormal levels or structure of the protein affect disease. Animal models may be valuable for such genotype-phenotype analysis and for determining mechanism of disease as well as...
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