Article
An evolutionary approach to folding small alpha-helical proteins that uses sequence information and an empirical guiding fitness function.
Proceedings of the National Academy of Sciences of the United States of America - 10 May 1994
Bowie J U, Eisenberg D
Abstract excerpt
Three short protein sequences have been guided by computer to folds resembling their crystal structures. Initially, peptide fragment conformations ranging in size from 9 to 25 residues were selected from a database of known protein structures. A fragment was selected if it was compatible with a segment of the sequence to be folded, as judged by three-dimensional profile scores. By linking the selected fragment...
Topics
- Algorithms
- Amino Acid Sequence
- Biological Evolution
- Models, Genetic
- Models, Molecular
- Mutation
- Protein Conformation
- Protein Folding
- Protein Structure, Secondary
- Proteins
- Recombination, Genetic