Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

10 May 1994

Abstract excerpt

An important limitation that has emerged in the use of adenoviruses for gene therapy has been loss of recombinant gene expression that occurs concurrent with the development of pathology in the organ expressing the transgene. We have used liver-directed approaches to gene therapy in mice to study mechanisms that underlie the problems with transient expression and pathology that have characterized in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8183921
DOI: 10.1073/pnas.91.10.4407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.PMID 8183921Read ↗

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.Semantic proximity Read ↗

Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivoSemantic proximity Read ↗

Adenovirus-mediated Gene Therapy of Liver DiseasesSemantic proximity Read ↗

In Vitro and In Vivo Biology of Recombinant Adenovirus Vectors with E1, E1/E2A, or E1/E4 DeletedSemantic proximity Read ↗

Two Key Challenges for Effective Adenovirus-Mediated Liver Gene Therapy:Innate Immune Responses and Hepatocyte-Specific TransductionSemantic proximity Read ↗

Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha.Semantic proximity Read ↗

Incomplete elimination of viral genomes is associated with chronic inflammation in nonhuman primate livers after AAV-mediated gene transferSemantic proximity Read ↗

Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following <i>In Vivo</i> AdministrationSemantic proximity Read ↗

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearanceSemantic proximity Read ↗

Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells.Semantic proximity Read ↗

Cytotoxic T-Lymphocyte Target Proteins and Their Major Histocompatibility Complex Class I Restriction in Response to Adenovirus Vectors Delivered to Mouse LiverSemantic proximity Read ↗

Interference with the IL-1-Signaling Pathway Improves the Toxicity Profile of Systemically Applied Adenovirus VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.