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Article

Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following <i>In Vivo</i> Administration

1 Jan 1997

Abstract excerpt

To evaluate the contribution of the innate immune component of host defense in clearing the genome of adenovirus (Ad) vectors following in vivo administration, the Ad vectors AdCMV.βgal (expressing β-galactosidase) or AdCMV.Null (expressing no gene) were administered intravenously to immunocompetent or immunodeficient mice, and the amount of vector genome was quantified in the liver. Strikingly, 90% of vector DNA...

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Identifiers

PMID: 8989993
DOI: 10.1089/hum.1997.8.1-37

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