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Article

Adenovirus-mediated Gene Therapy of Liver Diseases

1 Jan 1999

Abstract excerpt

Recombinant adenoviruses can infect nondividing cells with high efficiency and are rapidly concentrated in the liver after systemic administration, making them attractive for use in liver-directed gene therapy. However, there are two hurdles to clinical application of these vectors. First, adenoviruses are episomal and have limited life spans within the cell. Second, host antiviral immune responses reduce the...

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PMID: 10349683
DOI: 10.1055/s-2007-1007097

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