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Article

CSF ‐1‐activated macrophages are target‐directed and essential mediators of schwann cell dedifferentiation and dysfunction in C x32‐deficient mice

27 Jan 2015

Abstract excerpt

We investigated connexin 32 (Cx32)-deficient mice, a model for the X-linked form of Charcot-Marie-Tooth neuropathy (CMT1X), regarding the impact of low-grade inflammation on Schwann cell phenotype. Whereas we previously identified macrophages as amplifiers of the neuropathy, we now explicitly focus on the impact of the phagocytes on Schwann cell dedifferentiation, a so far not-yet addressed disease-related...

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PMID: 25628221
DOI: 10.1002/glia.22796

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